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Methyl isobutyl ketone (MIBK) is a ketone that is widely used as a solvent. Unlike the other common ketone solvents, acetone and MEK, MIBK has quite low solubility in water, allowing it to be used
for liquid-liquid extraction. It has a similar polarity to the ester solvent ethyl acetate, but higher stability towards aqueous acid or base than ethyl acetate.Methyl isobutyl ketone is
manufactured from acetone, via a three-step process. Firstly acetone is dimerised via the aldol condensation to give diacetone alcohol, which readily dehydrates to give mesityl oxide. Mesityl oxide
can then be hydrogenated to give MIBK.An explosion in August of 2008 in Institute, West Virginia near Charleston, West Virginia at a Bayer CropSciences chemical plant that killed one and badly
burned another involved this flammable solvent.[1]Synthesis of MIBK from acetone[edit] UsesIt is used as a solvent for CS in the preparation of the CS spray used currently by British police forces.
[2]When mixed with water or isopropyl alcohol it is also used as a developer for PMMA electron beam lithography resist.Another major use is as raw material in the preparation of
N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylene diamine (6PPD), an antiozonant used in tires. 6PPD is prepared by reductive coupling of MIBK with 4-aminodiphenylamine.[citation needed]Methyl isobutyl
ketone is also used as a denaturing agent for denatured alcohol.Methyl isobutyl ketone (MIBK) can be used to extract gold, silver and other precious metals from cyanide solutions, such as those
found on gold mines, to determine the levels of those dissolved metals. Another solution used for this purpose is diisobutyl ketone (DIBK).